Reptiles are one of the hardest subjects in macro photography. They're shy. They're fast. A few of them can hurt you. And most of them are wrapped in shiny scales that throw your flash straight back at the lens as a sheet of white glare.
I've spent years photographing snakes, lizards and geckos in the field. Here's how I do it.
The Camera Body: Weather Sealing and Megapixels
You don't need anything exotic. Two features matter more than the rest.
Weather sealing lets you go where the reptiles are. Wet grass, light rain, humid forest floor, riverbanks after dark. If you're nervous about your camera you'll stay on the path, and the good finds are never on the path.

Megapixels give you room to crop. That matters with animals that bolt or bite when you close the last ten centimetres. Shoot a little wider than you want, crop later, keep your fingers.
A flash is not optional. Macro lens photography lives at f/11 and smaller because depth of field at high magnification is measured in millimetres, something Cambridge in Colour explains well. Stop down that far and there's almost no light left. The flash puts it back.
Choosing a Macro Photography Lens for Scaly Subjects
You'll need two lenses. Reptiles come in wildly different sizes and no single lens covers both ends of that range.
The True Macro Lens: 90mm to 105mm
For full frame, stay in the 90mm to 105mm range. A 50mm macro reaches 1:1 too, but you have to get so close that you're almost touching the animal. Working distance is the whole point. It keeps glass out of the snake's face and leaves room to fit a macro diffuser in front of the lens.

Don't buy a macro photography lens for its autofocus. No macro lens focuses fast or accurately enough at high magnification for autofocus to be the deciding factor. You'll be rocking gently back and forth on your knees, focusing with your body. Everyone does.
The Wide Angle Macro Lens
Big reptiles need a different approach. A two metre snake photographed at 1:1 is a picture of three scales. Interesting, but it tells you nothing about the animal or where it lives.
A wide angle macro lens fixes that. On full frame you can go as wide as 15mm. The Laowa 15mm f/4 Wide Angle Macro is the one I keep coming back to, with a 110 degree view, true 1:1 magnification and a minimum focus distance of 12.2cm. It's fully manual, which nobody minds in macro work. A close focusing 24mm or 30mm lens does a similar job with less drama.

Micro Four Thirds shooters have it easy here. The OM System 12-45mm f/4 Pro focuses down to 12cm at the wide end and holds 0.5x equivalent magnification right across the zoom range, and it's weather sealed. DPReview covered the specifics when it launched. One small, sealed lens covering habitat shots and half life-size close-ups is a genuinely useful thing to carry.
Lighting Is the Whole Game
Reptiles are often active at night, so photographing them and using flash go hand in hand. Bare flash on scales is ugly. You get hard specular hotspots, crushed black shadows and a lizard that looks like it's been laminated.
Soft light fixes all of it. Light passing through a diffusion panel spreads out and the direction of the rays gets randomised. It reaches the animal from many angles instead of one, so shadows lift, highlights calm down and the fine texture of every scale survives.
Soft Boxes for the Bigger Reptiles
The most natural light comes from studio sized soft boxes. Great light, terrible for hiking. Portable folding versions like the SMDV Speedbox Flip series collapse into a pouch and open in about a second, so they're a real option for larger snakes and monitors. The catch is that somebody has to hold it, or you spend time mounting it on a stand while your subject leaves.
A Macro Flash Diffuser for the Small Stuff
Small reptiles are best photographed with a macro flash diffuser. These mount on a speedlight on the camera and place a large, soft panel of light right in front of the lens, exactly where you need it. Shadows soften, glare on shiny scales drops away, and both your hands stay on the camera.

That last part matters more than people expect. Handheld macro photography is the norm, not the exception, and anything that needs a second pair of hands will cost you shots.
We built the ProMacro Custom Diffuser around that reality. It's made to fit your exact camera, lens and flash, weighs from 80g on a carbon fibre frame, packs down to roughly 30 x 8cm, and works on camera or off camera with a handheld flash. You can see what that light does to scales and eyes in our gallery.
Twin Flashes and Ring Lights
Twin flashes give you light from two angles, which is genuinely useful. They're also fiddly to work with, and you'll need to build a custom diffuser for them if you want natural looking results. Bare twin flash heads are just two small hard sources instead of one.
Ring lights I avoid completely. They ring every scale and both eyes with a hard circular highlight, and the effect reads as a cheap phone edit rather than a wild animal.
Getting a Reptile to Hold Still
This is the hard part. Reptiles are afraid of us, and walking up to one usually means watching it vanish into the nearest crack.
Because of that, catching reptiles to photograph them is common practice. If done carefully it can be done without causing harm the animal. Reptiles are hardy. Always keep handling short, never work an animal to exhaustion, and release it exactly where you found it.

Venomous Snakes Deserve Extra Respect
The handful of venomous reptiles out there ask for a bit more care than the rest. Always value your fingers over a photo. I know how maddening it is when a snake slides out of frame for the fifth time before you've even pressed the shutter, but that's the moment to stay composed. Don't grab it by the tail to correct the pose. Don't try any other quick fix that puts your hand near the animal.
Use proper snake handling equipment with venomous species, every single time. A shield in front of the lens is a good idea too, and a see-through acrylic sheet with a cut-out for the lens does the job nicely. Often the diffuser itself gives you adequate protection already. Stay safe out there.
In-Situ Photography
In-situ photography means photographing an animal without catching or disturbing it. It's the ideal, and it's difficult. Fast lizards and nervous snakes usually mean reaching for a telephoto lens and accepting whatever light you're given.
Some species make it possible. Several pit vipers sit patiently for hours, and you can work slowly around them and build a proper image with your macro diffuser. When the animal lets you, take that option every time.
Why Reptiles Are Worth the Trouble
Photographing reptiles asks more of you than almost any other macro subject. They're elusive, they're reflective, they're often out at night, and half the time they're gone before your knees hit the ground.

That's exactly why the good frames feel so special. A gecko's eye rendered with soft, even light is one of the most beautiful things you can put in front of a lens, and no amount of editing gets you there afterward. It comes from the light you make in the field. If you want to work on that hands-on with us, come and shoot at the online ProMacro Atelier.
Get out there and find some scales!